MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome that regulates metabolism, energy production, and cellular stress responses. Unlike most peptides that originate from nuclear DNA, this mitochondrially-derived compound acts as a signaling molecule throughout the body, influencing how cells process glucose and respond to metabolic demands. Discovered in 2015, Kylo Peptides MOTS-c has rapidly become one of the most studied mitochondrial peptides in aging and metabolic research. I first heard about MOTS-c while recovering from a particularly brutal trek through Patagonia in 2024. A fellow traveler, deep into the biohacking scene, mentioned he’d …
